• EE 428/528 BioMEMS & Lab-on-a-chip, Lecture, 3 credits

• Covers various commonly used micro/nanofabrication techniques, microfluidics, various chemical and biochemical applications such as separation, implantable devices, drug delivery, and microsystems for cellular studies and tissue engineering. Discusses recent and future trends in BioMEMS and nanobiosensors. Students will gain a broad perspective in the area of micro/nano systems for biomedical and chemical applications.

• Fall 2008

• T/Th, 3:30 PM - 4:50 PM, 260 CAPEN

• Kwang W. Oh, Ph.D. (kwangoh@buffalo.edu)

• SMALL (nanobio Sensors and MicroActuators Learning Lab), http://www.SMALL.buffalo.edu

• Department of Electrical Engineering, University at Buffalo

• 215E Bonner Hall, North Campus, Buffalo, NY 14260

• Office Hours: Friday 10:00 AM – 12:00 AM or by appointment

• Graduate standing in engineering, medicine, biomedical sciences, and natural sciences or

• Senior undergraduate students (with permission only from the instructor)

• By the end of the course, students should be able to:

1. Review BioMEMS fabrication

2. Identify miniaturization issues on life sciences

3. Review various microfluidic platforms

4. Demonstrate creative solutions at the interface of biology and technology

• Class notes and Handouts. Course website will be announced when it is ready.

• Stefan Haeberle and Roland Zengerle, Microfluidic platforms for lab-on-a-chip applications,  Lab Chip, 2007 DOI: 10.1039/b706364b Critical Review

• Reyes D R, Iossifidis D, Auroux P–A and Manz A Micro total
  (articles) analysis systems: 1. Introduction, theory, and technology Anal. Chem. 74 2623–36, 2002

• Auroux P–A, Iossifidis D, Reyes D R and Manz A Micro total analysis systems: 2. Analytical standard operations and applications Anal. Chem. 74 2637–52, 2002

• Vilkner T, Janasek D and Manz A Micro total analysis systems: recent developments Anal. Chem. 76 3373–86, 2004

• uPetra S. Dittrich, Kaoru Tachikawa, and Andreas Manz 2006 Micro Total Analysis Systems. Latest Advancements and Trends Anal. Chem. 78, 3887-3908, 2006

• Oh K W and Ahn C H 2006 A review of microvalves J. Micromech. Microeng. 16 R13–R39

• A. Manz, H. Becker, Microsystem Technology in Chemistry and Life Sciences, Springer, 1999

• O. Geschke, H. Klank, and P. Telleman, Microsystem Engineering of Lab-on-a-chip Devices, John Wiley & Sons, 2nd Edition, 2004

• G. T. A. Kovacs, Micromachined Transducers Source Book, MacGraw-Hill, 1998

• N. –T. Nguyen, S. Wereley, Fundamentals and Applications of Microfluidics, Artech House Publishers, 2002

• Attendancy 10% (if you miss one lecture -0.5%)

• Presentation (10-min): 20%

• Presentation Workshop (15-min): 30%

• Final Exam (60-min): 40%

Presentation & Paper

• 1. Presentation (10-min): Pick one random noun from a dictionary. The noun must begin with the same letter that begins your last name or first name. For example, Kwang W. Oh would choose nouns that begin with the letter ¡°K¡± or ¡°O¡±. Now, add micro-, nano-, or bio- to the beginning of the noun, and speculate on any potential usefulness of the technology or application. At the end of class, 2 students present their works, approximately 10 min long. The grading (instructor: 50%, students: 50%) will be based on (1) the uniqueness and originality of your selections (30%), (2) realistic and detailed approach (30%), and (3) presentation skills (presentation structure, entertainment, easy understanding¡¦) (40%).

• 2. Presentation Workshop (15-min): Choose a BioMEMS/LOC system/device/application; Come up with a solution of a device/system that the students might think works better than existing solutions; All students present the following assignments, approximately 15 min long; The grading (instructor: 50%, students: 50%) will be based on (1) the uniqueness and originality of your selections (30%), (2) realistic and detailed approach (30%), and (3) presentation skills (presentation structure, entertainment, easy understanding¡¦) (40%).

• See an attached grading sheet. The sheet will be used to check your attendancy too.

The schedule is subject to change and changes to the published schedule will be announced in class.
¡¡

W	Lecture	Date	Lecture
			Presentation
1	[01]	08/26 T	Syllabus / Introduction to MEMS
	[02]	08/28 Th	Introduction to BioMEMS
2	[03]	09/02 T	MEMS Fabrication
	[04]	09/04 Th	BioMEMS Fabrication
	P1		01, 02
3	[05]	09/09 T	Miniaturization in the Life Sciences
	P2		03, 04
	[06]	09/11 Th	Microfluidics
	P3		05, 06
4	[07]	09/16 T	Capillary-driven Microfluidics
	P4		07, 08
	[08]	09/18 Th	Pressure-driven Microfludiics
	P5		09, 10
5	[09]	09/23 T	PDMS-Based Integrated Fluidic Circuits
	P6		11, 12
	[10]	09/25 Th	Centrifugal-driven Microfluidics
	P7		13, 14
6		09/30 T	No Class (Rosh Hashanah)
	[11]	10/02 Th	Electrokinetic-driven Microfluidics
	P8		15, 16
7	[12]	10/07 T	Electrowetting-based Microfluidics
	P9		17, 18
		10/09 Th	No Class (Yom Kippur)
8	[13]	10/14 T	Droplet-based Microfluidics
			MicroTAS 2008
	[14]	10/16 Th	Microvalve
			MicroTAS 2008
9	[15]	10/21 T	Micropump
	P10		19, 20
	[16]	10/23 Th	Microfluidics Components
	P11		21, 22
10	[17]	10/28 T	Drug Delivery Devices
	P12		23, 24
	[18]	10/30 Th	Neural Interfaces / Tissue Engineering
	P13		25, 26
11	[19]	11/04 T	Cells in Microfluidics
			Microfluidics 2008
	[20]	11/06 Th	MicroPCR
	P14		27, 28
12	[21]	11/11 T	Point-of-Care Test (POCT)
	P15		29, 30
	W1	11/13 Th	Workshop 1
			01, 02, 03, 04, 05
13	W2	11/18 T	Workshop 2
			06, 07, 08, 09, 10
	W3	11/20 Th	Workshop 3
			11, 12, 13, 14, 15
14	W4	11/25 T	Workshop 4
			16, 17, 18, 19, 20
		11/27 Th	No Class (Fall Recess & Thanksgiving)
15	W5	12/02 T	Workshop 5
			21, 22, 23, 24, 25
	W6	12/04 Th	Workshop 6
			26, 27, 28, 29, 30
16	Final Week		Final Exam (60-min)

• Proposed Syllabus